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Introduction: The Covid-19 pandemic has confronted nations with various challenges, including health challenges. Therefore, the present study conducted with the aim of investigating the knowledge, attitude and performance of the people of Lorestan province regarding the follow of personal and environmental hygiene to prevent of Covid-19. Methods: In this cross-sectional study, 337 people of Lorestan province conducted by random sampling method in 2022. The data collection tool was the knowledge, attitude and performance questionnaire designed by the researchers that validity and reliability confirmed. Data analyzed using SPSS19   software and T-Test, ANOVA and Pearson tests. Results: 59.9 of female participants with an average age of 29.20±8.16 years and the average age of males was 32.75±8.81years. The average knowledge, attitude and performance score was1.54±.29, 3.16±.47 and 4.19±.96 prospectively. Pearson's test showed that there was statistically significant relationship between knowledge, attitude and performance. Conclusion: According to the findings of the research, the scores of knowledge, attitude and performance were above the average, therefore, in order to prevent and control the disease of Covid-19, more training is needed to improve knowledge and attitude continuously.

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