Periodontitis and oral cancers are the most common oral diseases in the human population. The early diagnosis of oral diseases allows the efficient therapy of the patient. During oral diseases, resident cells in the affected tissue secrete exosomal microRNAs (miRNAs) into saliva. As these miRNAs have a crucial role in the pathogenesis of oral diseases, they have been suggested as non‐invasive and validated biomarkers in predicting periodontitis severity and cancer progression. Several attempts have been performed to evaluate the expression of salivary exosomal miRNAs in patients with periodontitis and oral cancers. Some miRNAs are differentially expressed in the saliva of the affected patients when compared to healthy individuals. These miRNAs are reviewed in this narrative review. Collectively, it seems that salivary exosomal microRNAs could be used as a diagnostic biomarker in oral diseases. However, further studies are required to validate them.

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Introduction: The spread of Covid-19 disease resulted in major public health problem around the world and the closure of dental clinics. Thus, millions of orthodontic patients were unable to complete their treatment. The present study aimed to investigate the problems of patients undergoing orthodontic treatment in Sari during the Coronavirus pandemic in 2021. Methods: This descriptive-analytical cross-sectional study was conducted on all patients who underwent active orthodontic treatment and referred to the dental clinics in Sari in 2021. The sample size was 200 people who were included in the study by a convenience sampling method. Data were collected by a standard questionnaire based on a Boostati study and analyzed in SPSS-22 software. Results: A total of 200 patients undergoing orthodontic treatment were included in the study. Among them, 153 patients (76.5%) were female and their mean age was 18.92 ± 7.23 years. Seventy patients (35%) did not receive orthodontic treatment during the Covid-19 pandemic and 58 patients (82.9%) missed their visit for one or two months.