The use of synthetic strong acid catalysts or lewis acid catalysts from metals often causes environmental problems at the end of a chemical reaction. In this research offers an alternative solution using kelubi fruit extract (Eleiodoxa conferta) as a green catalyst, especially in the synthesis of 3,4-dihydropyrimidin-2 (1H)-ones derivatives which are reported to be active as therapeutic and bioorganic chemistry. So the purpose of this research was to develop a green catalyst from natural fruit for the synthesis of 3,4-dihydropyrimidin-2 (1H)-ones using kelubi fruit. The Green catalysts are obtained from water extracts of kelubi fruit that are ripe. Then the catalyst is added to the reagent for the synthesis of pyrimidine derivatives that consist of urea, benzaldehyde, and ethyl acetoacetate (equivalent). As a comparison, HCl is used as an acid catalyst. The result is the highest yield (67,7%) at the use of 0,2 ml green catalyst and reaction time 180 minutes. Spectrum UV-Vis of characteristics compound has a maximum wavelength of 306 nm.

Tanaman herbal merupakan warisan kearifan lokal dalam upaya pengobatan dan mempertahankan kesehatan masyarakat. Secara tradisional masyarakat Kalimantan tengah menggunakan tanaman aka kalesi (Sphatolobus ferrogenus) sebagai obat-obatan tradisional yang cukup luas. Penelitian ini bertujuan untuk mengisolasi senyawa metabolit sekunder yang terdapat dalam ekstrak metanol kulit batang aka kalesi (Sphatolobus ferrogenus). Isolasi dilakukan dengan tahapan ekstraksi, fraksinansi dan purifikasi. Hasil penelitian didapatkan dua isolat yang telah diuji kemurniannya dengan metode kromatografi lapis tipis. Isolat diidentifikasi dengan spektroskopi 1H-NMR dan 13C-NMR didapatkan senyawa gliseril monostearate dan sigmasterol. Kedua senyawa diuji sifat antidiabetes dengan metode inhibitor enzim α-glukosidase. Aktivitas senyawa gliseril monostearate tidak aktif, sementara sigmasterol menunjukan aktivitas yang lemah dengan IC50= 388 ppm.

<p>Octahydroxanthene Compounds are bioactive substance which can be produced from benzaldehyde derivative. In this research, we have carried out transformation of vanilin from Indonesian natural product to octahydroxanthene derivatives compound at optimized reaction time and guanidine was used as a catalyst. Several spectroscopy methods such as IR, ¹H-NMR and GC-MS were used to confirm the structure of product. The percent yield from optimation product obtained was 91% with 96% of peak area.</p><p><br /><strong></strong></p>

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