Necrotizing fasciitis is a serious infection that originates in the subcutaneous tissues. We present a case of 52 years old male patient who developed preperitoneal and retroperitoneal necrotizing fasciitis 2 weeks after the start of Coronavirus-19 infection. Preoperative abdominal computed tomography with intravenous and oral contrast revealed pre and retroperitoneal spread of air loculi with turbid fluid patches within necrotic tissues. After surgical excision of the lesion, histopathological and microbiological examinations of the samples revealed necrotizing fasciitis. This is the first report of preperitoneal and retroperitoneal necrotizing fasciitis after Coronavirus-19 infection in 52 years old male with no history of trauma or immunocompromised condition. Coronavirus-19 infection may increase the liability of patients to develop overwhelming infection and it may also delay the patient presentation causing serious health-related emergencies. The findings of necrotizing fasciitis on clinical grounds or imaging studies can help in diagnosis as well as the surgical intervention and appropriate antibiotics can highly impact the prognosis and survival of the patient.