Polymorphonuclear leucocytes are the predominant cell type in the inflammatory infiltrate around mycetoma grains. Human leucocyte chemotaxis using cells from healthy subjects has been demonstrated using cytoplasmic antigens from 3 mycetoma agents: Madurella mycetomatis and Pseudallescheria boydii, both fungi, and Streptomyces somaliensis, an actinomycete. There was a statistically insignificant increase in chemotaxis in the presence of ketoconazole, but griseofulvin was a potent inhibitor of leucocyte movement. Griseofulvin has been used to improve the clinical appearances in eumycetoma (fungal mycetoma) cases which respond poorly to antifungal chemotherapy and it is suggested that its effect in this condition depends, in part, on its ability to inhibit leucocyte aggregation around mycetoma grains.

Comparative therapeutic effect of three types of antibiotics on pneumonia associated with klebsiella pneumoniae in boer goats.

No abstract

Down syndrome (DS) is congenital chromosomal disorder syndrome, (Trisomy 21) characterized by mental deficiency and growth retardation. The dental caries and gingivitis are noticed to be more common among this group of patients, associated with reduced resistance to infections. This study aims to assess the prevalence of oral diseases, poor oral hygiene and associated factors, among children with trisomy 21. This cross sectional facility-based study was conducted in Medani School for children with special needs, in central Sudan. The total number recruited was 93 special-needs school pupils. Cases with trisomy 21 were 33 and all were recruited in this study. Simplified WHO basic oral health assessment tests conducted by a dentist, were used to assess; (i) DMFT (ii) calculus deposit and calculus index (Oral Hygiene Index) and (iii) Gingivitis and periodontal index. Male: female ratio was 2:1.3. Parents were mainly unskillful workers and house-wives. Dental plaque was reported in 100% of cases, calculus in 26 (78.8%), gingivitis in 26 (78.8%), periodontitis in 10 (30.3%) and dental caries (100%). Delayed tooth eruption was reported in 13 (39.4%) of cases. Dental plaque index was 0.84%, calculus index was 0.55 and oral hygiene index was 1.39. This study showed a high prevalence of poor oral hygiene among children with DS. Many factors were incriminated. Raising awareness and involvement in care of oral hygiene by mothers and school staff is highly recommended