Chemical bonding is a material that has the characteristics of abstract concepts and many concepts that must be understood by students and the lack of ability of students in relating the concepts that have been learned in everyday life. The interactive e-module is an effective teaching material for improving students' science literacy. This research aims to develop prototype in the form of interactive e-module using adobe flash on chemical bond material to encourage students' science literacy. Type of research used is research and development with Nieeven model consist of 4 stages: (1) preliminary research stage, (2) stage prototyping stage, (3) summative evaluation stage, and (4) systematic reflection and documentation stage. The results of the development were validated by expert and practitioner validators using the instrument in the form of questionnaires and limited group trials to the X class students at the Islamic High School Al-Azhar NW Kayangan. Quantitative data of validation result are analyzed by percentage formula and effectiveness test result is calculated with N-gain. Qualitative data in the form of responses and suggestions for improvement of validators are used as consideration for revision of the developed prototype. In general, validator assessments of development outcomes were obtained by average percentage by expert validation 88%, 90% practicability of teachers, and 85% limited group trial results, and the results of the N-gain effectiveness test of 0.5. This shows that the developed e-modules are very feasible to proceed to a broader stage and can foster students' literacy skills.