Background: Superoxide dismutase is one of the most important antioxidant enzymes that protect cells against destructive effects of superoxide anion. Objectives: The aim of this study was to evaluate the association between the C47T polymorphism (rs4880) of the manganese superoxide dismutase (Mn-SOD) gene and the risk of malignant lymphoproliferative disorders (MLDs). Patients and Methods: Manganese superoxide dismutase polymorphism was genotyped using polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP) in 103 patients with MLDs and 103 healthy control subjects. Results: The frequencies of the CC, CT and TT genotypes were 29.1%, 51.5% and 19.4%, respectively, in patients with MLDs and 24.3%, 47.6% and 28.2%, respectively, in the control group. There were no statistical differences in the genotype or allele frequency of rs4880 between cases and controls. Conclusions: According to the fact that Mn-SOD gene polymorphisms have been considered as a major risk factor in some malignancies, this single center study did not find any association between the rs4880 polymorphism of the manganese superoxide dismutase gene and risk of MLDs.