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Different arrangements of variable‐speed turbo‐compressor units in a pipeline boosting station are investigated by estimating the exergy destruction and exergetic efficiency; a thermodynamic method for quantifying irreversibility. Fuel consumption is determined by using the performance curves of compressors and turbines that are unique for each turbo‐compressor. Exergy destruction values of eight possible configurations, including coolers, are estimated for a specific station and result in the following values: 2.932 kg s−1 fuel consumption, 132.13 MW exergy destruction, and 99.4 MW exergetic efficiency for the optimum configuration. The case study is focused on the transmission of sour gas through a 56 inch (1 inch=2.54 cm) pipeline. Corresponding state theory within a simple virial equation of state is used to determine the effect of H2S and CO2. The results show that the exergetic efficiency of each configuration depends on the operating conditions and number of compressors in use. The optimum configuration depends on the station delivery flow rate and its compression ratio.

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