The investigation carried out during two successive seasons of 2018 and 2019 to study the effect of various natural plant extracts; synthetic chemicals and certain combinations on yield and cluster weight of Ruby Seedless grape cultivar. The natural plant extracts included Moringa, Fulvic acid, Chitosan, Turmeric extract, Aloe vera and Seaweed extract, while the synthetic chemicals were GA 3 , Hydrogen peroxide (H 2 O 2 ) , Salicylic acid, Mepiquat chloride, Micronutrients and free amino acids. As well as certain combined treatments. The results revealed that most treatments significantly increased both yield and cluster weight. The best natural treatments in this regard were Chitosan extract; Seaweed extract and Fulvic acid while Salicylic acid recorded the best results of chemical compound. While; from the combination treatments, free amino acids + Fulvic acid produced the highest yield and cluster weight.

The aim of the current study is to focus on treatment response in patients with malignant pleural mesothelioma (mPm) treated with combination chemotherapy using cisplatin plus vinorelbine. Secondary endpoints included, toxicity, progression-free and overall survival. Patients and Methods: This prospective study included 26 patients with histologically proven unresectable mPm treated at Kasr El-Aini Center of Clinical Oncology and Nuclear medicine (NEmROCK) from march 2003 to August 2004. Patients were assigned to receive cisplatin 75mg/m 2 on day one and vinorelbine 25mg/m 2 on days one and 8 every three weeks. Results: All 26 patients had measurable disease and were assessed for response. Six patients had partial response (23%), 14 patients had stable disease (54%), and six patients had disease progression on therapy (23%). Toxicity was acceptable and no treatment-related deaths occurred. The median progression-free survival was 5.15 months and the median overall survival for was 10.3 months, with a 42.3% one-year survival. Conclusion: Cisplatin-vinorelbine combination is an effectve regimen for management of malignant pleural mesothelioma with a tolerable toxicity profile. Further studies with a larger number of patients is necessary.