The increasing prevalence of diseases in urban populations caused by poor living conditions and social inequities is a primary concern for cities, especially after the COVID-19 pandemic, highlighting a significant vulnerability to health disasters. This research identifies specific urban determinants of health, aims to bridge the gap between urban health and urban resilience, and examines the health risks associated with changes in urban mobility and green space. Through a literature review and empirical research of the case study of Heliopolis, Cairo, where site observations, satellite images and semi-structured interviews provide data for findings relating social and physical determinants with potential population health outcomes. Heliopolis is undergoing an urban mobility project intending to turn it into a large mobility axis. The findings underlined a significant reduction in walkable spaces, percentages of greenery, and a sense of safety, affecting the resident's lifestyles and space-use patterns and potentially leading to increased health risks, pollution, and disaster vulnerability. This research calls for relinking urban health and resilience, adopting a more preventative approach to health promotion, especially in global south cities.