A series of triazolophthalazine derivatives (4-22) were synthesized and characterized. The structures of the newly synthesized compounds were confirmed by spectral data. The newly synthesized compounds were also screened for their antimicrobial activity.Thioglycolic acid Aromatic aldehyde Knoevenagal reaction Cyanoacetohydrazide Antimicrobial activity 4-Benzyl-1-chlorophthalazine
A number of novel coumarin (4), pyridinone (5a,b), thiophenopyridinone (6), 1,2,3triazole (7), pyrazolotriazine (10), thiazole (11,14a,b,15), thiophene (12), thiazolidinone (20,21,23) derivatives were synthesized via interaction of 4-(1-(2-(2cyanoacetyl)hydrazono)ethyl)phenyltosylate (3) with different nucleophilic reagents. The structures of the newly synthesized compounds were confirmed by elemental analyses IR, 1 H-NMR and mass spectral data. All compounds were evaluated for their antimicrobial activities.
Some new pyrano [3,4-c]chromene derivatives (4,5,9,13,14), bispyrano [3,4-c]chromene derivative (18) were synthesized via Michael addition of different active methylene compounds to benzoylchromenes 1a,b under different reaction conditions. Chromeno[4',3':4,5]pyrano [2,3':4,5]pyrano[2,3-b]pyridine (24,28) derivatives were obtained from the condensation of 4 with formic acid and benzylidene malononitrile respectively. Novel chromeno[3,4-c]pyridine derivatives (34,37,40,43) and chromeno[3,4-c]tetrahydroquinolinedione (47) were obtained via treatment of 2-iminochromene-3-(4-ethoxyphenyl)-carboxamide (31) with acetonitrile derivatives and cyclohexanone respectively. The structures of the titled compounds cited in this article were elucidated by spectroscopic data (IR, 1 HNMR and mass spectra). The antimicrobial activities of the synthesized compounds were performed and some of them display significant results.
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