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Background: Neurohumoral activation of the heart can be monitored by measurements of systemic levels of natriuretic peptides, such as BNP. Patients with non ST-elevation myocardial infarction (NSTEMI) with elevated BNP levels had an increased mortality rate when compared with those with lower levels. The SYNTAX score is a novel anatomical tool characterizing coronary vasculature and grades the complexity of coronary artery disease. Patients and methods: The study included 58 patients with NSTEMI ''Group I'' (72.5%) and 22 patients as a control ''Group II'' (27.5%) with typical chest pain, and coronary angiography revealed healthy coronaries. Analysis of blood samples for troponin-I, CKMB, and BNP levels was performed within 24 h of hospital admission, all patients underwent echocardiographic examination to exclude systolic dysfunction. Both groups were referred to coronary angiography. Results: This study included 58 patients with NSTEMI ''Group I'' (72.5%) and 22 patients as a control ''Group II'' (27.5%), the serum level of BNP was significantly higher in patients with the NSTEMI ''group I'' (37.7 ± 32.06) than the control ''group II'' (1.82 ± 5.9) p value (0.0001). The levels of BNP were positively correlated with the LAD involvement in coronary angiography. There was a positive correlation between the serum level of BNP and number of coronary vessels involved (r = 0.75) and Degree of SYNTAX score (r = 0.78). Conclusion: There was a significant relationship between the serum level of BNP and number of coronary arteries involved and complexity of the lesions in NSTEMI as regards SYNTAX score.

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The study was applied on a total of 115 urine samples, collected from suspected cattle (97) and their in-contact dogs (18), which suffered from different clinical signs of leptospirosis. The collected samples were examined for Leptospira spp. by different methods as Dark Field Microscopy (DFM) and staining by Silver Impregnation Method "Fontana Method". The results of DFM showed that, 28 out of 97 (28.9%) cattle urine samples were positive, and eight out of 18 (44.4%) dogs' urine samples were positive. Additionally, the results of Fontana Method revealed that, 44 out of 97 (45.4%) cattle urine samples were positive, and 13 out of 18 (72.2%) dogs' urine samples were positive. To confirm these results, conventional polymerase chain reaction (PCR) targeting (23S rDNA) gene of Leptospira, was done on 6 urine samples, included 3 cattle urine samples and 3 dogs' urine samples (one sample was positive, and two samples were negative in each species). PCR result confirmed the DFM and Fontana method results. In addition, a treatment trial for three groups of cattle infected with leptospirosis was performed by Dihydrostreptomycin, Oxytetracycline and Amoxicillin, respectively for 3 days. This study showed higher prevalence of leptospirosis in Dakahlia by DFM and Fontana methods. Moreover, Dihydrostreptomycin, Oxytetracycline and Amoxicillin have been successfully affecting on leptospirosis.