Background: After achievement of parathyroid autotransplantation, thyroid autotransplantation was presented with goal of preventing or lessening severity of post-thyroidectomy hypothyroidism in noncompliant patients. Goal and objectives: In this research, we intended to evaluate efficacy of autotransplantation of thyroid tissue after total thyroidectomy (TT) in benign thyroid disorders to keep the patient euthyroid with no need for life long hormone replacement therapy. Studied cases and methods:The study included thirty patients with benign thyroid disorders for whom total thyroidectomy was done. Autotransplantation was done by excising an apparently healthy portion weighing about 2-5 gm from the resected thyroid gland after total thyroidectomy and slicing this portion into about 10 small fragments then inserting these fragments into pocket made in the sternomastoid muscle. Follow up process contained measurement of serum levels of T3, T4 and TSH and thyroid scanning by 99mTC-MIBI scintigraphy. Results: Serum calcium level following total thyroidectomy: 28 patients had normal serum calcium level (8.5mg/dl-10.5mg/dl) and only 2 patients developed hypocalcaemia. These 2 patients were advised to take oral calcium to correct hypocalcaemia with regular follow up. Conclusion: Thyroid autotransplantation after total thyroidectomy is effective way to avoid postoperative hypothyroidism in benign thyroid disorders.