Introduction Hyponatremia is one of the most common water–electrolyte imbalances in the human organism. This disorder is usually secondary to various diseases, including infections. The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is among causes of hyponatremia in critical care. It can be induced by a variety of conditions, including atypical lung disease. Discussion The COVID-19 infection is associated with multiples metabolic disorders. However, hyponatremia associated with SIADH and Coronavirus disease 2019 (COVID-19) is not a usual clinical situation, but it was recently mentioned in a few case reports. Conclusion We discuss a unique case of an acute symptomatic hyponatremia and SIADH, attributed to COVID-19.

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