Background: Spontaneous threatened abortion is a painful or painless vaginal bleeding from a closed cervix in the condition of positive embryo cardiac pulsations in the first 20 weeks of pregnancy. Most of pregnant women look for urgent obstetrician consultation in early pregnancy because of sudden abdominal pain with or without vaginal bleeding . Aim of the work: aimed to declare the relation between maternal serum progesterone level and serum BHCG level in case of threatened abortion and their prediction role of the end result of that abortion. Patients and Methods: : The study was carried out at El Hussien and Om El Masreen hospitals. 200 patients on the 5 th -12 th week of gestation with first trimester threatened abortion were included in our study Results: Regarding patient`s age, GA, HB and BMI, there is showed no significant difference between the groups. In our study, BHCG and progesterone are markedly acceptable to anticipate abortion end result with a cutoff value of B-HCG and Progesterone which was (18153 mIU/ml ,23.5 ng/ml). The sensitivity, specificity for B_HCG at 18153 mIU/ml were 100% and 98.2%, respectively, for Progesterone at 23.5 ng/ml 83% and 89% respectively. Conclusion:In case of threatened abortion, using BHCG to anticipate the end result is more reliable than progesterone. Moreover, The assaying of BHCG and progesterone together does not add any benefits on sensitivity ,while specificity increased from 98.2% to 100%.