The aim of this study is to evaluate the importance of toxicological analysis in acute intoxications by pesticides through the experience of the laboratory of the Poison Control and Pharmacovigilance Center of Morocco (CAPM). This is a retrospective study from January 2014 to September 2020, concerning suspected pesticides poisoning cases. The cholinesterase activity was measured in whole blood and the chromatographic analyzes (GC-MS and LC-MS-MS) were conducted in blood, urine and gastric lavage fluid. In this study, 398 tests were involved. The median age of the patients was 14 with an interquartile range of [4-26 years]. The sex ratio (F / M) was 1.5. The requests were from the region of Rabat-Salé-Kénitra in 82.8% of cases (north-western Morocco). The cholinesterase activity measurement was performed for 295 patients with low values in 3.7% of cases. The toxicological screening by GC-MS and LC-MS-MS detected the pesticide responsible of poisoning in 62 cases as insecticides in 38% of cases, redenticides (33% of cases) and herbicides (5% of cases). Toxicological analysis plays an essential role in the diagnosis and the management of acute pesticides poisoning. Interpretation of results is carried over by analyst with close cooperation with clinical toxicologist.

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Introduction: Methanol intoxication is a public health problem that mainly affects poor populations in developed and developing countries. Despite all the advanced treatment methods, high mortality rates are still observed due to late admission to hospital and late diagnosis and treatment. Many mass poisoning have been described, following the misuse of methanol in the manufacture of adulterated alcohol in some Eastern European, Asian and African countries, resulting in several hundred each year. Objective: The objective of our study was to describe four cases of methanol intoxication that were received by the au toxicology and pharmacology laboratory of the Moroccan poison control centre CAPM-LAB. Materiel and methods: The epidemiological characteristics of patients intoxicated and dying by methanol in a collective setting were described as well as the results. Ethanol and methanol were determined in whole blood by gas chromatography with a flame ionisation detector coupled to the Head speace (CPG-FID-HS). Results: Following the consumption of adulterated alcohol (locally prepared alcohol); the CAPM-LAB received three samples from the city of El-Hajeb. The patients were aged of 46, 58 and 26 years and presented visual and consciousness disorders and vomiting, they presented average methanolemia of 1,34g/l. The CAPM-LAB also received samples from another patient from the city of Marrakech, aged 44 years, following a collective intoxication (three people) with adulterated alcohol, with methanol level of 2,52g/l. The patients died as a result of heart failure. Conclusion: Methanol can cause fatal intoxication, due to its easy availability in our country and the illegal production of alcoholic beverages.