ABSTRACTa gradual progressive course for the last two weeks. He presented with recurrent attacks of vomiting and confusion that rapidly worsened. Neurologically, the patient was confused and uncooperative with recurrent attacks of vomiting and bradycardia but no other neurological symptoms or signs. Computed tomography (CT) and magnetic resonance imaging (MRI) showed a well-demarcated enhancing spaceoccupying lesion, that was partially cystic, partially calcified in the subependymal area of the left frontal lobe partially projecting into the frontal horn of the lateral ventricle and causing obstructive hydrocephalus (Figure 1). We managed the patient as an urgent case in our intensive care unit (ICU) and performed urgent external ventricular drainage to manage the increased intracranial pressure (ICP). About one week later, we performed surgery for tumor resection by left frontal craniotomy. The tumor was pink-yellow in color, highly vascular, soft in consistency in parts and firm and calcified in other parts and was partially succable and well circumscribed which allowed total resection of the tumor. After the surgery, the patient ws transported routinely to the ICU for 3 days. Follow-up CT showed gross total resection (GTR) with mild postoperative brain edema at the site of surgery. The patient was followed up periodically every month for the first 3 months and then every 6 months without postoperative chemotherapy or radiotherapy and without recurrence. After one year, he showed a recurrent mass at the same site as the primary lesion in the follow-up MRI that was managed █ INTRODUCTION A stroblastoma is a rare glial tumor of the brain. It is estimated to account for 0.45-2.8% of all primary cerebral gliomas (1,30,31). Astroblastomas are initially described by Bailey and Cushing (3) and further characterized by Bailey and Bucy (2). However, much confusion has arisen regarding criteria for their diagnosis in the following years. Moreover, the origin of these tumors has been debated, because they share common histological characteristics with ependymomas and astrocytomas. Recent studies suggested that astroblastoma is a distinct histological and genetic entity (6,7,31,39). It has a distinctive characteristic of perivascular pseudorosettes with frequent vascular hyalinization. Perivascular pseudorosettes in astroblastoma have short and thick cytoplasmic processes and blunt-ended foot plates (30).We introduced a case of astroblastoma and reviewed all relevant literature of astroblastoma in order to discuss astroblastoma from the clinical, pathological, management, and prognostic view points. We tried to discover more secrets of astroblastoma and to introduce a standard approach to its diagnosis and management. █ CASE REPORTA forty-year old male patient complained of headache, nausea, vomiting, and deterioration of conscious level with Astroblastoma is a rare and distinct type of aggressive glial tumor for which there is much confusion regarding the diagnostic criteria. We present a case of astroblastoma and review...
The ethanolic extract of pomegranate molasses was investigated for its impact on phenylhydrazine (PHZ)-induced anemia in male albino rats using LCMS/MS analysis to determine the phytoconstituents. When PHZ was administered,red cells (RBCs) decreased in count, hematocrit, haemoglobin concentration, and mean cell volume (MCV) were increased. Mean corpuscular haemoglobin (MCH) and concentration, as well as reticulocyte count, leukocyte count, and platelet count were the same results. PHZ also caused hyperbilirubinemia, an increase in erythropoietin, iron, lactate dehydrogenase, and malondialdehyde levels, as well as a decrease in the activity of the antioxidant enzymes and glucose-6-phosphate dehydrogenase (G6PD). Additionally, PHZ caused the splenic histopathology to deteriorate. The administration of molasses prior to PHZ provided protection against RBCs abnormalities, increased RBCs count, hematocrit, and haemoglobin concentration, and decreased MCH, leukocyte count, platelets count, and reticulocyte count. Additionally, the administration of molasses prior to PHZ decreased the levels of bilirubin, erythropoietin, iron, lactate dehydrogenase, and malondialdehyde and increased the activity of G6PD and antioxidant enzymes. In comparison to administration of PHZ alone, the administration of molasses before PHZ led to a modrest improvement in splenic histopathology. Finally, the pomegranate molasses ethanolic extract exhibits good protection against blood poisoning and anemia caused by PHZ and may be a promising choice for treating anemia-related disorders with a natural origin.
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