Objectives: To determine the common clinical presentations, common aetiological factors, average age at presentation and possible means of early detection of cholestasis by primary health care workers. Method: This prospective, descriptive study analyzed 60 infants less than six months old who presented to Lady Ridgeway Hospital from October 2013 to January 2015 with evidence of cholestasis. Results: The common clinical features were jaundice (100%), hepatomegaly (83.3%), pale stools (76.6%), dark urine (61.6%) and splenomegaly (56.6%). The common causes were idiopathic neonatal hepatitis (INHS) (26.6%) and biliary atresia (26.6%). Nine cases of INHS were transient. Sepsis (15%), multifactorial (13.3%) and cytomegalovirus infection (6.6%) were the other frequent causes. The less frequent causes were Alagille syndrome (3.2%), birth asphyxia (1.6 %), progressive familial intrahepatic cholestasis (PFIC) (1.6%), biliary sludge due to haemolysis (1.6%), intestinal obstruction (1.6%) and multiple small gall bladder calculi (1.6%). The average age at presentation of infants with cholestasis was 64.2 days and the mean age at presentation of infants with cholestasis who were eventually diagnosed as biliary atresia was 81.8 days.