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The main aim of this study was to evaluate the in vivo behavior of three novel bioactive composites based on wollastonite ceramic (W) and soda-lime-silica glass. The ratio of wollastonite (50, 60 and 70 wt. %) was increased at the expense of the glass ratio. The novel composites were coded as WG55, WG64 and WG73, respectively. The formed composites were implanted into bone defects created in femurs of rats and remained for three months. All composites were able to regenerate bone defects as reveals by histological analysis, SEM/EDX examination, and bone density measurements. The results showed that more bone was developed in defects as the wollastonite ratio was increased in the composites. EDX analysis indicated that the newly formed bone by all composites was mineralized bone having a Ca/P molar ratio around 1.55. This value was close to that of healthy normal bone (1.56). The mineral density of the formed bone was 205.58±14.93 for WG55, 195.66±17.59 for WG64, and 190.63±12.68 mg cm −3 for WG73. The value recorded for WG73 samples was the closest to that of healthy bone (156±20.12).

The aim of the present work is to evaluate the effect of caffeine, the world's most popular psychoactive drug, on the electric activity of the rat's brain that exposed to extremely low-frequency magnetic field (ELF-MF), during 15 days. The obtained results showed that administration of caffeine in a group of rats by dose of 10 mg/kg (equivalent to human daily consumption) caused a reduction in the mean power amplitude of electroencephalogram (EEG) trace for almost all frequency bands especially α (8-12 Hz). It was observed that the influence of caffeine was more evident in motor cortex than in visual cortex. While the exposure of another group to ELF-MF of intensity 0.2 mT during the same period caused an enhancement in the mean power amplitude of most EEG frequency bands; this was more observed in the right hemisphere of the brain than that of the left hemisphere. The administration of caffeine while rats were exposed to ELF-MF, led, after 5 days of exposure, to a great increase in the mean power amplitude of α band at all places of recording electrodes. It may be concluded that caffeine administration was more effective in reducing the hazardous of ELF-MF in motor cortex than in visual cortex.

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