In the present investigation, aluminium-based alloy (AA6082) is stir-casted with 3 % ZrO2 and 5 % B4C reinforcement particulates to fabricate Aluminium Metal Matrix Hybrid Composites (AMMHCs) which are further friction-stir welded at different welding conditions to develop a welded joint with optimum ultimate tensile strength (UTS) and microhardness. This newly developed AMMHC will find its specific application as bulkhead partitions in the hull of a ship due to its excellent properties, such as lower weight, higher specific strength, superior resistance to wear, and lower thermal expansion coefficient than that of AA6061 and AA5083 composites. The friction-welded butt joints performance of AA6082/3%ZrO2/5%B4C is generally determined by varying the FSW process parameters such as tool rotational speed (TRS), welding speed (WS), axial load (AL), tool tilt angle (TTA), tool pin profile (TPP), shoulder diameter (SD), etc. In the present work, the empirical relationships are established between parameters highly influencing FSW process (TRS, WS, and AL) and their responses (UTS and weld nugget microhardness (WNH)). The desirability approach is employed for predicting the optimal UTS and WNH. The corresponding values of input process parameters are TRS of 1030.95 rpm, WS of 38.5 mm/min, and AL of 5.88 kN. The calculated UTS and WNH for the present investigation are 239.98 MPa and 94.2 HV, respectively, and these values are consistent with the results of validation experiments.