No abstract

To overcome the recent outbreaks of hepatotoxicity-related drugs, a new analytical tool for the continuously determination of these drugs in human fluids is required. Electrochemical-based analytical methods offer an effective, rapid, and simple tool for on-site determination of various organic and inorganic species. However, the design of a sensitive, selective, stable, and reproducible sensor is still a major challenge. In the present manuscript, a facile, one-pot hydrothermal synthesis of bismuth oxide (BiO) nanostructures (nanorods) was developed. These BiO nanorods were cast onto mass disposable graphite screen-printed electrodes (BiO-SPEs), allowing the ultrasensitive determination of acetaminophen (APAP) in the presence of its common interference isoniazid (INH), which are both found in drug samples. The simultaneous electroanalytical sensing using BiO-SPEs exhibited strong electrocatalytic activity toward the sensing of APAP and INH with an enhanced analytical signal (voltammetric peak) over that achievable at unmodified (bare) SPEs. The electroanalytical sensing of APAP and INH are possible with accessible linear ranges from 0.5 to 1250 μM and 5 to 1760 μM with limits of detection (3σ) of 30 nM and 1.85 μM, respectively. The stability, reproducibility, and repeatability of BiO-SPE were also investigated. The BiO-SPEs were evaluated toward the sensing of APAP and INH in human serum, urine, saliva, and tablet samples. The results presented in this paper demonstrate that BiO-SPEs sensing platforms provide a potential candidate for the accurate determination of APAP and INH within human fluids and pharmaceutical formulations.

Nanozyme-based electrochemical sensors have attracted much attention because of their low cost, sensitivity and remarkable stability under extensive environmental and industrial conditions. Interestingly, the physical characteristics of the nanomaterials in terms of size, shape, composition, surface area and porosity dominate the electrochemical processes at electrode surfaces. Herein, we explore nickel oxide nanoplatelets (NPs) modified screen-printed electrode-based nanozyme sensors that displays high electrochemical activity including stability, sensitivity, selectivity and applicability for organophosphate pesticide (Parathion) determination. Differential pulse voltammogram of NiO-SPE in presence of parathion showed a characteristic peak current at -1.0 V (vs. Ag/AgCl). The NiO-SPE platform allows determination of parathion over the concentration range of 0.1-30 µM with a limit of detection (LOD) of 0.024 µM. The sensing platform is found to detect parathion of interferences without compromising the sensitivity of the sensor. Such interesting features offer a sensitive determination of parathion in water, urine and vegetable samples.

The development of flexible, sustainable, and efficient energy storage has recently attracted considerable attention to satisfy the demand for huge energy and power density and meet future societal and environmental needs. Consequently, numerous studies have focused on the design/development of nanomaterials based on mesoporous architectures to improve energy and power densities. We explored how nanoarchitectures in term of morphology, particle size, surface area, and pore size/distribution define energy and power performance. The large-scale production, low-cost manufacturing, and highperformance of supercapacitors based on the microwave-assisted synthesis of mesoporous nickel oxide nanocrystals (NCs) were presented. Mesoporous NiO in various morphologies including nanoslices (NSs) and nanoplatelets (NPLs), were synthesized. The superior electrochemical performance of mesoporous NiO NPLs is related to their unique morphology, size, and pore size distribution, which enhance the diffusion of hydroxide ions through mesoporous networks, i.e. "superhighways". These characteristics induce the high capacitance and excellent recyclability of NiO NPLs more than NiO NSs. Moreover, the microwave-assisted synthesis enhanced charge storage and stability compared with those prepared through the hydrothermal approach. This approach demonstrates the potential of free-standing NiO NPL electrodes for developing high-performance pseudocapacitors.

No abstract