Background: Prevalence of inguinal hernia worldwide is 15%-45% at different ages that requires surgical repair. At present, inguinalprotrusion (hernia) is a common surgical method with mesh repair. The modern mesh type includes a variety of materials, and surgical options include using fixation mesh, sutures, rigging or staples, self-meshes and fibrin-fixation, or other types of glue. Aim of the work:To assess and compare the efficacy of mesh fixation using fibrin glue, tacks and sutures during laparoscopic repair of inguinal-protrusion. Patients and methods: Randomized-study involved; 15 male-patients presented with inguinal-protrusion (hernia) at Al-Azhar university hospitals using laparoscopic trans-abdominal pre-peritoneal repair. According to the mesh fixation method, Patients were divided into three different groups: Group 1: using fibrin glue, Group 2: using staple, and Group 3: using sutures. Results: Age were no statistically significant difference between groups. Operative time was highly statistically significant difference between groups there were no intra-operative complications in all groups. Postoperative pain score shows highly statistically significant differences between groups in all follow up time except after 6 months there were no statistically significant differences between groups. Early post-operative, hospital stay, Economic Cost complications were no statistically significant differences between groups. There was no Recurrence found at follow up in all groups. Conclusion: Our study revealed that fibrin glue method is considered comparable, cost effective method for mesh fixation. According to our findings; observed that fibrin glue have fast recovery, less hospital stay, cost effective, less complications and low recurrence rate.