Background: Generally ventricular septal defects (VSDs) are repaired with synthetic material: either Dacron (polyethylene terephthalate) or Goretex (expanded polytetrafluoroethylene) depending on surgeons preference. Aim of the work: To compare between the outcome of VSD closure by synthetic patches versus pericardial patches. Patients and methods: This study was conducted on 60 patients with surgical VSD closure. They were divided into 2 groups each included 30 patients. In group I synthetic patch (Dacron or Gortex) was used. In group II pericardial patch (fresh or treated or bovine) was used. The patients were evaluated at 3m and 6m after operation for: residual defects, endocarditis, heart block, AR, TR, LV dimensions and function and any other complications. Results: Ventilation time, was statistically significant shorter in group II (8.53 ± 6.37h) compared with Group I (30.60 ± 20.84h) p value 0.001*. Statistically significant shorter ICU time was found in group II (2.53 ± 0.90d) compared with group I (3.70 ± 1.62d). Twenty (66.7%) patients and 28(93.3%) patients in group I and II respectively had sinus rhythm. While 10 (33.3%) patients and 2 (6.7%) patients in group I and II respectively had temporary heart block.