All obstetricians have the primary objective of obtaining an optimum obstetric and perinatal result. Diagnosis of many obstetric complications, such as restriction of intrauterine development, preeclampsia; placental necrosis or early pregnancy abruption may be conducted through several safe tests to minimize maternal and fetal morbidity or mortality. Biochemical markers were used for the earl during the 1980s and 90s. Early detection of fetal genetic disorders was performed using biochemical markers. Soon after the establishment of maternal serum screening tests for early detection of fetal abnormalities, poor pregnancy results started to be reported after unexplained isolated alpha-fetoprotein (AFP) elevation was identified. This correlation was recorded between high AFP and poor obstetric outcomes Recorded over the last 20 years. In this paper, we attempt to investigate recently updated data on the relationship between high levels of maternal serum alpha-fetoprotein (MS-AFP) with various obstetric and fetal outcomes and to assess its significance as effective markers in predicting poor outcomes for pregnancies The aim of the study: The aim of our study was to detect the significance of AFP in obstetric medicine. Conclusion: As a result of our research, unexplained AFP rates have been discovered with unfavorable perinatal results. Pregnancies in which AFP rates increasing rapidly were complicated with adverse perinatal outcomes in a more serious manner.