Introduction: Obturation with a fluid tight seal has a direct impact on the success of root canal treatment; therefore, sealer bonding and adaptability are critical parameters.Aim: This in-vitro study compared two different root canal sealers with two different obturation techniques in terms of adaptability and push-out bond strength.Materials and methods: Forty extracted single rooted lower premolars were prepared. The samples were divided into two groups (n=20). Group I was obturated with well-Root ST sealer and group II was obturated with ADSEAL sealer. Each group was subdivided into two subgroups (n=10). Subgroup A was obturated with single cone technique and subgroup B was obturated with cold lateral compaction technique. Each subgroup was divided into two subdivisions (n=5). Subdivision 1 for adaptability evaluation and subdivision 2 for push-out bond strength evaluation. Specimens were then sectioned horizontally. Adaptability was evaluated using scanning electron microscope and push-out bond strength was assessed using universal testing machine.Results: Well-Root ST showed higher push-out bond strength and better adaptability than ADSEAL. Cold lateral compaction technique showed higher push-out bond strength than single cone technique, while no significant difference was found between the two techniques regarding adaptability. Middle and apical sections showed higher push-out bond strength and better adaptability than coronal sections. Conclusion:Within the limitation of this study, bio-ceramic sealers are promising root canal sealers. Cold lateral compaction technique improves the push-out bond strength of the root canal sealer; however, technique of obturation showed no significant effect on adaptability.