No abstract

Objectives: The present study was performed to compare between two different fixation techniques and evaluate the histopathological changes which occur in temporomandibular joint (TMJ) of the dogs after surgically induced unilateral subcondylar fracture. Methods: Twenty- One healthy beagle male dogs with a mean age of 30 months were used in the present study. One of these animals was sacrificed to study the normal histology of the dog TMJ. The rest of the animals (20 animals) were operated on to induce a displaced unilateral subcondylar fracture then, the animals were randomly equally divided into 2 groups. After surgery, 5 dogs of each group were sacrificed at 2 months after surgery (Short-Term), while the remaining 5 were sacrificed at 4 months after surgery (Long-Term). The heads were separated and fixed, oscillating saw was used to articulate the entire TMJ. Specimens were decalcified, then the specimens were washed, grossed and sectioned in a sagittal plane. Tissue sections of 4 um thick were cut and stained with Hematoxylin and Eosin to be studied microscopically. Results: In group I animals, at 2 months after surgery, there was a marked hypertrophy of the articular fibrous covering of the condylar head, while at 4 months after surgery, the articular fibrous covering appeared thinner than normal, with marked decrease in thickness of the articular cartilage layer. In group II, at 2 months after plate insertion, the articular fibrous covering became hypertrophic, and the articular cartilage was markedly reduced but it was of a uniform thickness, while at 4 months after subcondylar fracture and plate fixation, no significant changes could be detected either in thickness or structure of the articular fibrous covering. Conclusion: Based on this study, it is obvious that the plate fixation group gave the most favorable results, when compared with maxillomandibular fixation (MMF) group.

(1) Background: The present study was carried out to provide new information about the relation between angiogenesis, tumor stage Oral squamous cell carcinoma (OSCC); (2) Materials and methods: Thirty formalin-fixed paraffin embedded blocks were used, 10 of them were previously diagnosed as well differentiated OSCC, 10 moderate differentiated OSCC and 10 poorly differentiated OSCC. To determine the expression of CD31 and D2-40 proteins, streptavidin-biotin immunoperoxidase staining technique was used. The areas with the most vascular density (hot spots) were determined. The stained vessels were counted independently in intratumoral and peritumoral stroma in five areas of hot spot at ×400 magnification; (3) Results: Immunohistochemical staining using CD 31 protein showed that CD31-positive vessels in the peritumoral and intratumoral stroma subjacent to the malignant invading nests which was recorded highest values in poor differentiated OSSC followed by moderate differentiated OSSC then well differentiated OSSC. D2-40 expression was positive in lymphatic vessel in the peritumoral and intratumoral stroma subjacent to the malignant invading nests. Poorly differentiated OSSC tissue sections recorded the highest vessels count followed by moderate differentiated OSSC then well differentiated OSSC. There was statistically significant difference found between the three studied groups regarding CD31 and D2-40 levels. Also there was statistically significant positive correlation found between CD31 level and D2-40 level and vice versa; (4) Conclusion: CD31 and D2-40 are related to stage of OSCC and are consistent with angiogenesis in tumor progression.

The aim of this retrospective study was to assess, clinically and by MRI the short and long term effect of unilateral mandibular segmental repair by reconstruction plate on the ipsilateral and contralateral TMJ. 18 adult patients (12 male & 6 female) with history of mandibular reconstruction by titanium reconstruction bone plate were included. The age range was 32-66 years (mean 49years). The condyle in the reconstruction side was preserved. Based on the follow up period following the reconstruction, three groups were established. Magnetic resonance imaging was performed for all patients at the recommended follow up periods. Clinical examination also was done for all the patients in the same intervals. The result of this study demonstrated that there were no statistically significant differences noted between the three groups regarding the clinical data and also there were no significant differences between the MRI findings in all groups.

Purpose: The present study was performed to evaluate clinically, radiographically and histologically the effect of autologous platelet rich fibrin (PRF) and 1% alendronate (ALN) gel in alveolar ridge preservation after tooth extraction. Materials and method: In this study, thirty patients with teeth indicated for extraction were divided randomly into three groups: Group A: the patients received 1% ALN gel mixed with PRF as a grafting material for the extraction socket. Group B: the patients received PRF only and in Group C the socket left without any a grafting material. All patients were evaluated clinically and radiographically at; base line and after 3 months. Also, histological evaluation using bone core biopsy harvested at the re-entry surgery before implant placement. Results of the present study were recorded, tabulated and statistically analyzed. Results: Histological, clinical and radiographic findings showed a statistically significant difference in group A when compared to both group B and group C. Conclusions: The addition of ALN to PRF leaded to a noticeable socket preservation and reduction in the amount of bone resorption during the observation period of the study.