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Two case histories of patients with end-stage renal disease subsequently found to have primary hyperoxaluria are reported. In the setting of renal failure, the diagnosis is both difficult, due to diminished oxalate excretion, and important, because of frequent graft loss due to oxalate deposition after renal transplantation. The diagnosis was obtained by renal and bone biopsies. Plasma oxalate levels were normal in one patient and the other patient presented with extensive cystic bone lesions. Primary hyperoxaluria should be considered whenever nephrocalcinosis and/or nephrolithiasis are associated with end-stage renal disease.

coagulation factors deficiency; hereditary coagulation factor V deficiency; hereditary protein C deficiency A 34-year-old Saudi female was referred to our centre with a diagnosis of renal failure and pregnancy. She was well until 2 days prior to admission, when she developed nausea and blood-streaked vomiting. She was gravida 8, para 7; all children were alive and well