The traffic on the roads in many countries has been increasing in recent decades, and the increases in congestion and carbon emission are contributing significantly to climate change. To minimize these adverse effects, the use of more sustainable travel modes, such as public transit, walking, bicycling, carpool and ridesharing, has been widely promoted. Apart from these travel modes, alternatives, such as teleworking, which reduces commute trips, should also be promoted. The objective of this study is to identify different neighborhood design and social characteristics that are associated with teleworking. In this case study, a multiple regression model is applied to 2011 census data and road infrastructure data of 185 communities from the city of Calgary in Canada. In addition, a random intercept model is estimated to account for unobserved heterogeneity. We find that different street patterns, geographical size, land use, mass rapid transit, and road types have a significant effect on teleworking or working-at-home and should be considered when designing new communities. We also find several significant sociodemographic characteristics, including family size, marital status, children, housing type and language. Policy implications based on this research are then provided.