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The iron coordination and biological chemistry of a series of heterocyclic dithiocarbazate Schiff base ligands is reported with regard to their activity as Fe chelators for the treatment of Fe overload and also cancer. The ligands are analogous to tridentate heterocyclic hydrazone and thiosemicarbazone chelators we have studied previously which bear NNO and NNS donor sets. The dithiocarbazate Schiff base ligands in this work also are NNS chelators and form stable low spin ferric and ferrous complexes and both have been isolated. In addition an unusual hydroxylated ligand derivative has been identified via an Fe-induced oxidation reaction. X-ray crystallographic and spectroscopic characterisation of these complexes has been carried out and also the electrochemical properties have been investigated. All Fe complexes exhibit totally reversible Fe(III/II) couples in mixed aqueous solvents at potentials higher than found in analogous thiosemicarbazone Fe complexes. The ability of the dithiocarbazate Schiff base ligands to mobilise Fe from cells and also to prevent Fe uptake from transferrin was examined and all ligands were effective in chelating intracellular Fe relative to known controls such as the clinically important Fe chelator desferrioxamine. The Schiff base ligands derived from 2-pyridinecarbaldehyde were non-toxic to SK-N-MC neuroepithelioma (cancer) cells but those derived from the ketones 2-acetylpyridine and di-2-pyridyl ketone exhibited significant antiproliferative activity.

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Wireless communication networks are highly prone to security threats. The major applications of wireless communication networks are in military, business, healthcare, retail, and transportations. These systems use wired, cellular, or adhoc networks. Wireless sensor networks, actuator networks, and vehicular networks have received a great attention in society and industry. In recent years, the Internet of Things (IoT) has received considerable research attention. The IoT is considered as future of the internet. In future, IoT will play a vital role and will change our living styles, standards, as well as business models. The usage of IoT in different applications is expected to rise rapidly in the coming years. The IoT allows billions of devices, peoples, and services to connect with others and exchange information. Due to the increased usage of IoT devices, the IoT networks are prone to various security attacks. The deployment of efficient security and privacy protocols in IoT networks is extremely needed to ensure confidentiality, authentication, access control, and integrity, among others. In this paper, an extensive comprehensive study on security and privacy issues in IoT networks is provided.