Background: Over the past few decades, chronic kidney disease (CKD) with high serum creatinine has turned into an intensive clinical and epidemiological research in Bangladesh as well as globally. Even though the transparency provided by the Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines, there appears to be within the CKD with high serum creatinine research literature significant dissimilarity on how to define CKD and assess kidney function. In this situation homeopathic symptomatic treatment can play a vital role in CKD with high creatinine. Methods: The cases of four patients with CKD and high creatinine from our observations are discussed, those whom were benefited by homeopathic treatment. The more common remedies administered in the treatment of CKD with high creatinine include: Lycopodium clavatum, Apis mellifica, Apocynum cannabinum, Aurum muriticum, Cuprum metalicum Cantharis,  Sarsaparilla, Glonoine, Serum anguillae, Berbaris vulgaris,… etc. The patho-physiologies, diagnosis, review of CKD and serum creatinine are discussed. These case study analyses of CKD emphasize that a consideration of CKD symptoms with high serum creatinine, in addition to more constitutional symptoms, is important when homeopathically analyzing these cases. Results: The positive effects of different homeopathic medicines were clearly reducing serum creatinine during the treatment of CKD patients without hemodialysis with cost effectiveness and most harmless way. Conclusions: These case study analyses found that early proper diagnosis, most appropriate selection of homeopathic remedies and follow-up is important to cure the CKD with high serum creatinine and possible resulting renal failure can be dreadful.