Cervical vertebroplasty is a successful operation for decompression of the spinal cord and optimum restoration of cervical lordosis in individuals with severe canal stenosis. In this research, we demonstrate our method of reconstruction and replacement to the cervical vertebral body disorders with an expandable titanium cage or polyetheretherketone (PEEK). Neurologic status, morbidity, and mortality were evaluated before and after the surgery. We conducted a single-center, prospective study for all patients with cervical vertebral body lesions, who underwent single-stage vertebrectomy with an expandable titanium cage or PEEK, plate and screws reconstruction of the vertebral body. The study period between January 2014 and June 2020 in Al- Azhar university hospitals. The study included 25 patients who underwent single-stage, anterior-approach surgery. We used an expandable titanium mesh cage in five of them, and the other 20 were reconstructed using PEEK, plate, and screws. All patients had neurological symptoms before surgery, including brachialgia, motor deficit, or sphincter problems. The mean follow-up was 45.7 months (1-65 months). Neurological improvement was recorded in 20 patients at the last follow-up time, and five patients were not improved.