Hypoxia most often occurs in cancer and the occurrence of hypoxia helps the cells in adapting different responses than the normal such as the activation of of those signaling pathways which regulate proliferation, angiogenesis, and cell death. There are large number of genes which are known to be associated with diverse biological processes and their control and coordination and in different cancers, the hypoxia-response differs. In this study our goal is to understand the impact of alteration in expression of hypoxia and immune systems related genes and its survival in breast cancer and analyzed the hallmarks of molecular signatures. For this purpose we have collected the hypoxia-associated genes based on the literature related with diverse biological processes and functions. For all these genes, we have studied the survival analysis, breast cancer gene expression profiling, and relevant hypoxic genes alterations. Based on our study, we conclude that there are 17 critical pathways and 40 genes from hypoxic gene list appear to play the major roles in case of breast cancer and overall we observe that immune signaling pathways and its components are highly altered in case of breast cancer. Among the top raked hallmarks of molecular signatures are apoptosis, hypoxia, DNA repair, E2F targets, MYC targets, androgen and estrogen response, and TNFa signaling.

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Background: Dengue virus is a potential source of propagating dengue hemorrhagic fever. This virus leads to dengue hemorrhagic fever/dengue shock syndrome, benign syndrome, and severe syndrome and due to its infection there occurs alterations at multiple levels such as gene expression and the pathway levels. So, it is critical to understand the pathogenesis of dengue infection in terms of gene expression and the associated functions. Methods: For this purpose, here, we have analyzed the temporal gene expression profiling for dengue hemorrhagic fever dataset at 12, 24, and 48 hours. Results: The outcome appears that the dengue hemorrhagic fever evolve differently at different time periods or stages. Counclusions: The change in gene expression pattern increases exponentially from 12 hours to 48 hours and the number of altered functions (pathways) also increases. Wnt, apoptosis, transcription signaling are among the critical pathways which are dominantly altered. In the initial phase (first 12 hours) only two pathways are altered due to dengue infection while in the next 12 hours, eight pathways are altered, and finally in the next 24 hours 11 pathways are altered and most of these 11 pathways are very critical in terms of biological pathways and functions.

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