Background: The sedentary lifestyle violates health status and has negative impacts on the quality of life with subsequently numerous diseases. Objectives: The current study aimed at evaluating the quality of life outcomes of Iranian traditional medicine (ITM) health protection measures instruction (traditionally named Hefzalsehe meaning that the essential lifestyle recommendations to maintain health and well-being based on ITM). Methods: The current randomized, controlled trial aimed at examining the quality of life outcomes of ITM health protection measures instruction (Hefzalsehe) in individuals in Tehran, Iran in 2017. At the same interval, the experimental group was trained virtually and traditionally for the ITM health protection measures; whereas the control group was not. Subsequently, the Persian version of the short-form 12 quality of life questionnaire (SF-12) standardized in former studies was applied to measure the effect of Hefzalsehe instruction on the quality of life of 101 subjects randomly assigned to two demographically-matched groups. Results: Significant improvement was observed in physical functioning (19.12 vs.-20.5; P < 0.001), role constraints due to physical problems (42.16 vs.-34; P < 0.001), bodily pain (16.67 vs.-11; P < 0.001), general health (14.71 vs.-12.5; P < 0.001), vitality (12.55 vs.-2; P < 0.001), social functioning (18.14 vs.-12; P < 0.001), role constraints due to emotional problems (35.29 vs.-16; P < 0.001), and mental health (14.51 vs.-4.2; P < 0.001) in the experimental group compared with the control group. Conclusions: The current study indicated positive effects of education and Hefzalsehe instruction on the quality of life parameters.
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