Background New cases of oropharyngeal squamous cell carcinoma (OPSCC) are routinely tested for HPV. HPV in saliva can be detected with PCR, but its clinical applicability in the context of OPSCC remains unknown. Methods Forty‐six consecutive patients diagnosed with OPSCC had pre‐treatment saliva specimens collected. PCR for HPV on saliva was compared to p16 IHC and HPV DNA in situ hybridisation (ISH) on surgical biopsies. Results The sensitivity and specificity of saliva testing when compared to the reference test of p16 IHC and HPV DNA ISH were 72.2% and 90%, and positive and negative predictive values were 96.3% and 47.4%. There were no adverse events. Time from last meal, smoking, alcohol drinking and physical exercise did not impact on results. Conclusions Saliva testing is a promising test to detect HPV in patients with OPSCC. A positive result could avoid the need for surgical biopsies, thereby reducing costs, patient morbidity and expedite treatment.

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Background: Proper patient selection for most appropriate treatment option for hepatic hydatid is crucial to ensure successful treatment outcome. Chemotherapy, newer approaches, like PAIR procedure, (puncture, aspiration, injection and reaspiration) laparoscopy are available. As the indications for these approaches are restricted, surgery remains the key treatment strategy with hope for complete cure. Radical surgical excision coupled with chemotherapy and long-term aggressive chemotherapy for partially resected ensures lowest morbidity and mortality. Methods: This cross sectional observational study of 15-year single-institution experience, intended to further validate different surgical procedures in management of hydatid disease of liver and its outcome. Patients were randomly selected irrespective of their age, sex and mode of presentation. Different preferred surgical treatment modalities, perioperative complications, recurrences, and length of hospital stay were retrospectively analyzed. Result: The study was carried out on 79 Bangladeshi patients diagnosed hepatic hydatidosis, treated surgically from January 2002 to December 2017 in BIRDEM General Hospital. Among them was no anastomotic leakage or mortality in the immediate postoperative period in our series. Conclusion: This study revealed, proper case selection and consideration of risks-benefits, indicationscontraindications for each case of Hydatid cyst of liver, for making a decision for type and timing of surgery is key to successful outcome. Surgery is the mainstay of treatment strategy. Radical surgery is key to effective and successful outcome, ensures better quality of life and prevents recurrence of the disease. Journal of Surgical Sciences (2018) Vol. 22 (2) : 118-124

: Natural products are well known for their high potency with minimum side effects. Plant extracts are the most commonly used natural products because of their ease of availability and relatively low production cost. Berberine (BBR), a phytochemical component of some Chinese medicinal herbs (most commonlyBerberis vulgaris), is an isoquinoline alkaloid with several biological and pharmacological effects including antioxidant, anti‐inflammatory, antitumour, antimicrobial, antidepressant,hepatoprotective, hypolipidemic, and hypoglycemic actions. Interestingly, multiple studies have shown that BBR is a potential drug candidate with a multi-spectrum therapeutic application. However, the oral delivery of BBR is challenged owing to its poor bioavailability. Therefore, its oral bioavailability needs to be enhanced before it can be used in many clinical applications. This review provides an overview of the various studies that support the broad range of pharmacological activities of BBR. Also, it includes a section to address the issues and challenges related with the drug and methods to improve the properties of BBR such as solubility, stability and bioavailability that may be explored to help patients reap the maximum benefit from this potentially useful drug.