Objective: To evaluate the combined effect of single preoperative dose of dexamethasone and ibuprofen in comparison to dexamethasone alone on postoperative pain, swelling and trismus after third molar surgery. Methods: Sixty patients (35 males, 25 females), underwent surgical extraction for their partially impacted lower third molar. Patients were allocated into three groups. In the first group (n=20), 8mg of (2ml) dexamethasone was injected intramuscularly into the deltoid muscle one hour before the operation, while in the second group (n=20), 8mg of (2ml) dexamethasone was injected intramuscularly into the deltoid muscle and 600mg ibuprofen was administered one hour before the operation. In the third (control) group (n=20), 2ml of normal saline was injected intramuscularly. Pain, swelling and trismus were evaluated postoperatively. The data were collected and statistically analyzed using (ANOVA) test. Results: There was no significant difference among the groups (control, dexamethasone, and dexamethasone-ibuprofen groups) in pain intensities showed by visual analogue scale. Postoperative swelling was significantly less in dexamethasone, and dexamethasone-ibuprofen groups in comparison with the control group. Smaller loss of mouth opening postoperatively was noted in dexamethasoneibuprofen group compared to the other two groups. Conclusion: The combination of preoperative dexamethasone and ibuprofen is associated with reduced pain, trismus, and swelling after dental surgical procedures.