A new Ag(i) metal–organic framework (Ag-MOF) [Ag(p-OH-C6H4COOH)2(NO3)]n [Ag(PHBA)2(NO3)]n, (1) (PHBA: C8H6O4 {p-hydroxybenzoic acid}) was synthesized using two different methods; the laying method (single crystal) and sonochemical irradiation (nanostructures).

Nozar Fayaz bakhsh 10 this scenario was designed to investigate the protein corona pattern on the pillar-layer surface of a Cu-based metal-organic framework (MOF) in human plasma. The [Cu(L)(L /)].1.3DMA (MOF-1) {L = 4, 4 /-bipyridine and L / = 5-aminoisophthalic acid}, was synthesized through the sonochemical irradiation approach as well as characterized by various techniques like scanning electron microscopy, Fouriertransform infrared spectroscopy, X-ray powder diffraction and single-crystal X-ray diffraction. The space group was determined to be an orthorhombic space group (Pbam) by single-crystal X-ray diffraction. Single-crystal X-ray analyses on MOF-1 showed that Cu +2 ion was 6-coordinated. Besides, to study and clarify interactions between MOFs and biological milieu, human whole blood plasma was selected as a model. Fluorescence spectroscopy and SDS-PAGE techniques were employed to explore quantitative and qualitative in situ characterization of protein corona as well. Furthermore, cell viability in a cancerous cell lines was evaluated by MTT assay in the presence and absence of the corona. The results from SDS-PAGE illustrated that the most adsorbed quantity among plasma proteins belongs to fibrinogen (α, β and γ chains), and this protein showed the maximum frequency on the MOF-1s surface, so the possible interactions of MOF-1s with fibrinogen also studied using fluorescence spectroscopy and corresponding data were plotted. According to the obtained data from MTT assay, these structures have concentration-dependent toxicity. In brief, based on the obtained data in the current study, the designed MOF can be introduced as a new desirable carrier for drug/gen delivery after further prerequisite assessments. Identification of the proteins that surround nanoparticles may have remarkable effects on the clearance, biodistribution, and toxicity of them. The role of protein-nanoparticle interactions in nanomedicine has begun to the development of the term nanoparticle-protein corona which is classified into two types based on protein affinity toward the NP surface: (a) high affinity proteins which binds tightly to NPs (hard corona) and (b) low affinity proteins whose adsorption is dynamic, and freely exchange during the time 1-4. Metal-organic frameworks (MOFs), are porous coordinated networks comprised of metal cations/clusters, the desired group of porous crystalline with exceptional features including tunable structure, high porosity, ultrahigh

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Nanoparticles of two zinc(II) coordination polymers (CPs), [Zn(μ-4,4'-bipy)Cl] (1) and [Zn(μ-4,4'-bipy)Br] (2) L=bpy=4,4'-bipyridine ligand, have been synthesized by use of a sonochemical process and characterized by scanning electron microscopy (SEM), X-ray powder diffraction (XRPD), Fourier transform infrared spectroscopy (FTIR) spectroscopy and elemental analyses. The single crystal X-ray data of compounds 1 and 2 imply that the Zn ions are four coordinated. Topological analysis shows that 1D coordination networks of 1 and 2 can be classified as underlying nets of topological types 2C1. Nanoparticles of zinc(II) oxide have been prepared by calcination of two different zinc (II) CPs at 450°C that were characterized by scanning electron microscopy (SEM), X-ray powder diffraction (XRD) and IR spectroscopy.