Damage or loss of the bone tissue leads to mobility decline contributing to one of the major issues of human well-being. Tissue engineering is used to recover fractures and damaged parts of the bone tissue. Various biomaterials and scaffolds have been evaluated for regeneration of hard tissues, however, polymers are the most frequently required biomaterials for the improvement of synthetic bone scaffolds due to their suitable mechanical properties and similar degradation rates to the proteins in hard and soft tissues. Synthetic polymeric materials in bone replacement have several advantages because their physical characteristics can be designed according to their application and their composition can be changed easily. On the other hand, the high adaptability, tenability, and biocompatibility of synthetic materials have received considerable acceptance in the field of tissue engineering. This article presents an update on materials for the fabrication of scaffolds in bone tissue engineering; in addition, we provide information of different kinds of scaffolds and their application usage for hard tissue regeneration.

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