Background: Fatigue is one of the most common and annoying symptoms in patients with multiple sclerosis (MS). The purpose of this study was to investigate the effect of sensory interventions on fatigue in people with MS based on a systematic review of sensory evidence. Methods: The Google Scholar, PubMed, Scopus, and Cochrane Library databases were searched from January 1990 to July 2020. Studies with nonpharmacologic sensory interventions as a main or secondary intervention according to the assessment of fatigue as the primary or secondary therapy outcome in patients with MS were included. Results: Nine articles were reviewed by examining the inclusion and exclusion criteria. Four types of interventions were related to exercises, including sensory integration exercises, vestibular rehabilitation, Frenkel exercises, and exercises with or without vibration; and two types were performed using robots and one type using vibration only. Vestibular rehabilitation therapies, exercise-based sensory integration interventions, and the use of vibration have shown significant effects in relieving fatigue in patients with MS. Conclusions: The evidence in this study is insufficient to show a dramatic effect of sensory integration therapy in various forms. However, despite the studies, sensory integration therapy can be considered a potential treatment for fatigue in patients with MS. Further studies with stronger methods are needed to make this treatment a reality.

Background and Objectives: Neuro Myelitis Optica (NMO) is a rare progressive and disabling autoimmune disease. The disabling consequences of the disease affect many aspects of the patients and their family life. multidisciplinary rehabilitation can be very effective in promoting quality of life and slowing disease progression by working with different disciplines. The aim of this study is to report the effects of multidisciplinary rehabilitation on the performance and quality of life of a patient with NMO and her family. Case Report: This study reports a six-month multidisciplinary rehabilitation program conducted for a woman with NMO and her caregiver. The rehabilitation team included the patient’s caregiver, a neurologist, an occupational therapist, and a speech therapist. The approaches of stabilization and recovery, maintenance, modification, and prevention were used through 70 sessions of occupational therapy. Also, the occupational performance was assessed with the Canadian Occupational Performance Measure. Furthermore, the Persian version of SF36 was used to assess the quality of life. The speech therapy intervention was performed in 24 sessions and included breath strengthening exercises, sound therapy, and laryngeal muscle manipulation. After six months, the results showed a great improvement in the quality of life of the patient and her caregiver. Conclusion: The use of team approaches in the face of progressive neurodegenerative diseases such as NMO has a significant impact on improving the quality of life of these patients and their families.