Introduction: One of the most common nosocomial infections is urinary tract infection (UTI), which more commonly seen in patients with urethral catheter. Inappropriate use of urinary catheter can lead to certain complications including infection. Objectives: The aim of this study was to evaluate the effect of using mupirocin and betadineimpregnated urethral catheters in comparison with conventional catheterization on the incidence rate of catheter-related bacteriuria (CRB) and UTIs. Patients and Methods: In this parallel randomized clinical trial, phase III, a total of 150 patients (male and female) ranging from 18-75 years who needed urinary catheterization were randomly assigned into three evenly distributed groups; betadine, mupirocin, and conventional (control) through permuted block randomization. Sterile urine samples were examined for bacteriuria after catheter insertion and at the time of catheter removal. Results: The mean age of the patients was 49.81 (±15.11) years. UTI was seen most frequently in the conventional group (56%), and least frequently in the mupirocin group (24%) (P<0.004). A significant difference was observed in incidence of post-catheterization UTI between the conventional and mupirocin groups, as well as between the conventional and betadine groups (P=0.001 and P=0.04, respectively). Conclusion: Using antibiotic and antiseptic-impregnated catheters (both mupirocin and betadine) could help to decrease the incidence rate of UTI in comparison to the conventional catheterization. Trial registration: The trial was registered with the TCTR ID: TCTR20200627001 (http:// www.clinicaltrials.in.th/index.php?tp=regtrials&menu=trialsearch&smenu=fulltext&task=s earch&task2=view1&id=6442).

Introduction: One of the most common nosocomial infections is urinary tract infection (UTI) which more commonly occurs in patients with urethral catheter. Objectives: The aim of this study is to compare the incidence rate of catheter-associated bacteriuria (CRB) and UTI between sheathed designed catheters versus other methods of urinary drainage. Patients and Methods: In this randomized double-blind controlled trial, 150 male patients, who needed urethral catheter, were randomly assigned into three groups; condom bag, designed sheath catheter and traditional Foley catheter. The midstream urine samples were sent to laboratory to evaluate bacteriuria immediately after catheter insertion, upon catheter removal and after two weeks consequently. Results: The mean age of patients was 51.28 ± 14.12 years. The frequency of bacteriuria in patients was 19 (38%), 10 (20%) and 10 (20%) in the traditional catheter, condom bag and sheathed designed catheter, respectively, which was strongly significant (P<0.001). Conclusion: The frequency of bacteriuria in the patients with designed sheathed catheter was significantly less than the traditional catheter. Therefore, using the designed catheter in short-term may be safer in the patients. Trial registration: The trial was registered in the Thai Clinical Trials Registry (identifier: TCTR20200703002; http://www.clinicaltrials.in.th/index.php?tp=regtrials & menu=trialsear ch & smenu=fulltext & task=search & task2=view1& id=6443).

According to the findings of the present study, in short-term catheterization, replacing sterile urine bag was more effective in decreasing bacteriuria and urinary tract infections (UTIs) as compared with the conventional method of urinary catheterization.