Objectives: CRP (C -reactive protein) is more often used to show hidden infections with the bacterial origin. CRP is most likely activated due to bacterial infection. The researcher in this study examined the effect of selenase on acute phase protein response. Methods: In this clinical trial, all patients were men and women in the age range of 20 -90 years old who were suffering from septic shock and the presence of positive bacterial cultures, Peoria, positive radiographic abscess, pneumonia, cellulites, gangrene, and infection in the presence of a urinary catheter that since the adoption of the proposal were admitted. To evaluate the mean level changes of plasma variables in the two groups, t-student test was used. The software used for statistical analysis was SPSS-18 and statistical values less than 0.05 were considered significant (P < 0.05). Results: Laboratory findings where markers of the acute phase response were examined in this study include the increased platelet count and CRP. Both variables in the two groups were statistically significant (P < 0.05). The frequency of patients who had a platelet count below 150,000 dL in the case group (selenium) was 5 patients and in the control group (placebo) was 9 individuals. This decrease in platelet count among patients was in the 70,000 -120,000 range. In the control group, elevated levels of CRP in test results was observed in the 13 patients and in the case group, this increase was seen in 8 patients. Conclusions: Effect of the acute phase response for detection infection in patients with sepsis is still controversial. This study showed the positive effect of Selenium on patients who have suffered from septic shock.