Background: Many women with breast cancer in the process of diagnosing, treating, and surviving show psychological distress such as hopelessness and cancer-related stress. On the other hand, Acceptance and Commitment Therapy (ACT) as a psychological intervention provides a good model for coping with the disease. Objectives: This study aimed at investigating the effectiveness of ACT on demoralization syndrome and cancer-related trauma in patients with breast cancer and survivors. Methods: The present study was a clinical trial with pre-test and post-test. It was performed on 52 patients with breast cancer and survivors referred to the Golestan Cancer Patients Association in Gorgan in 2020. Initially, participants were selected by convenient sampling and randomly divided into two treatment groups (patients group and survivors group) and two control groups (patients group and survivors group). Then, the treatment groups underwent ACT for 8 consecutive weekly sessions, but the control groups did not receive any intervention. The data were obtained, using the Demoralization Scale (DS) and Post-traumatic Stress Disorder Checklist for DSM-5 (PCL-5) and analyzed by multivariate analysis of covariance (MANCOVA). Results: The results of the study showed a significant difference in demoralization syndrome components and PCL-5 between the treatment groups of patients and survivors with control groups of patients and survivors (P < 0.05). Also, there was no significant difference between the treatment groups of patients and survivors in the components of demoralization and PCL-5 (P > 0.05) except for the feeling of failure component (P = 0.048). Conclusions: According to the results, using ACT as a complementary treatment along with medical treatment to prevent and reduce demoralization syndrome and cancer-related trauma is recommended in patients with breast cancer and survivors.

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