Background: Premenstrual disorders are characterized by emotional and physical symptoms. Millions of women around the globe who are of reproductive age experience premenstrual symptoms. Premenstrual syndrome (PMS) and premenstrual dysphoric disorder are two examples of these illnesses (PMDD) which have insightful effects on quality of life and major health consequences. Objective: This research set out to evaluate the occurrence and intensity of premenstrual syndrome (PMS) and to find the correlation between PMS and the body mass index (BMI) among reproductive females in Al-Madinah Al-Munawwara, Saudi Arabia. Methods: A crosssectional study was carried out on 392 females in the reproductive period.The diagnostic and statistical standards for measuring PMS served as the foundation for the Premenstrual Syndrome Scale (PSS). PMS was diagnosed when five or more symptoms were present. PMS subsided after menstruation (adapted from the American Psychiatric Association). The data were analyzed descriptively using (SPSS). Results: 77% and 55% of the 392 participants reported emotional or physical PMS, respectively. Also, there was a statistically significant link (p=0.048) between increasing BMI and increasing the severity of the emotional and psycho-behavioral symptoms. Conclusion:According to the findings of the current study, there was a direct relationship between PMS and BMI among reproductive females in Al-Madinah Al-Munawara, Saudi Arabia. Obesity should be incorporated into the PMS management plan as a modifiable risk factor, especially for those with severe symptoms that impair their quality of life.