Here, an impressive heterogeneous catalytic system, graphitic carbon nitride supported tris(hydroxymethyl)aminomethanem) g-C3N4/ THAM) is presented. The novel g-C3N4/ THAM nanocatalysts was characterized by analyzing methods such as FT-IR, EDX, XRD, TGA, and FESEM. Afterward, the performance of fabricated nanocatalyst g-C3N4/ THAM was suitably investigated in multicomponent reactions (MCRs) for the synthesis of 1,4-dihydropyridine and pyranopyrazole derivatives. By optimizing reported nanocatalyst, the corresponding reaction products were obtained with excellent efficiency and then the reversibility process was exanimated. The g-C3N4/ THAM nanocatalyst is environmentally friendly and was catalyzed the reactions in the presence of ethanol as a green solvent.
Objective:
KF/Clinoptilolite nanoparticles are employed as as a heterogeneous catalyst for the preparation of pyrido[2,1-a]isoquinoline derivatives through a four-component reaction of isoquinoline, two different alkyl bromides and an electron deficient internal alkynes at ambient temperature in water as green solvent.
Methods:
In this research, (2,2-Diphenyl-1-picrylhydrazyl) radical trapping and reducing potential of ferric ion experiments was used for determining antioxidant activity of some newly synthesized compounds such as 5a, 5c, 5f and 5g and comparing results with synthetic antioxidants (TBHQ and BHT).
Results:
Compounds 5a, 5c, 5f and 5g display trace DPPH radical trapping and excellent reducing power of ferric ion. Furthermore, the power of some prepared compounds against Gram-positive and Gram-negative bacteria was proved by employing the disk dispersion experiment.
Conclusion:
The obtained results of disk diffusion test showed that compounds 5a, 5d and 5e prevented the bacterial growth. The reported procedure shows the advantages of clean reaction, high yield and simple purification.
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