No abstract

: A novel viral respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-C0V-2), is responsible for a pandemic situation in the world. Pregnant women are susceptible against this virus due to physiologic changes of immunologic system. Some adverse pregnancy outcome such as; death, still birth, preeclampsia, intra uterine fetal distress may increase in infected pregnant women. Infected women should be isolated and investigated and they should admit in a designated hospital with adequate facilities and multi-disciplinary expertise to manage them. Some adverse neonatal complication such as; Small for Gestational Age, Large for Gestational Age, shortness of breath, thrombocytopenia with abnormal liver function, rapid heart rate, vomiting and pneumothorax may increase in affected neonate. This study reviews the problems and guidelines of covid-19 in pregnancy. The limitation of this study was; we didn’t conduct systematic review among studies were done in pregnancy and COVID 19.

Leptospirosis is known as a zoonotic disease of global importance originated from infection with the spirochete bacterium Leptospira. Although several leptospirosis vaccines have been tested, the vaccination is relatively unsuccessful in clinical application despite decades of research. Therefore, this study was conducted to predict B cell epitopes of the hemolysis-associated protein 1 (Hap1) for vaccine design against leptospirosis. For prediction of linear epitopes, the sequence of extracellular region of Hap1 was submitted to ABCpred, BCPREDs, Bcepred, Bepipred and Ellipro servers. DiscoTope 2.0 and B-pred servers were used for prediction of conformational epitopes from the entire PDB structure of Hap1 that obtained from the homology modeling method. Further analysis for solvent accessible areas and relative solvent accessibility of all the residues on the PDB structures using Naccess program and NetSurfP server defined that predicted conformational B cell epitopes had higher solvent accessible and their residues were exposed on the surface therefore, immunoinformatics analysis showed that hemolysis-associated protein 1 can properly stimulate the B cells immune responses.

New coronavirus disease 2019 , as a pandemic disaster, has drawn the attention of researchers in various fields to discover suitable therapeutic approaches for the management of COVID-19 patients. Currently, there are many worries about the rapid spread of COVID-19; there is no approved treatment for this infectious disease, despite many efforts to develop therapeutic procedures for COVID-19. Emerging evidence shows that mesenchymal stromal/stem cell (MSC) therapy can be a suitable option for the management of COVID-19. These cells have many biological features (including the potential of differentiation, high safety and effectiveness, secretion of trophic factors and immunoregulatory features) that make them suitable for the treatment of various diseases. However, some studies have questioned the positive role of MSC therapy in the treatment of COVID-19. Accordingly, in this paper, we will focus on the therapeutic impacts of MSCs and their critical role in cytokine storm of COVID-19 patients.