Introduction: Respiratory distress is a prevalent and serious consequence of neonatal sepsis, premature birth and neonatal pneumonia which is responsible for more than half of all neonatal fatalities worldwide. Objective: To assess the use of low-cost bubble continuous positive airway pressure in neonates with respiratory distress at a tertiary care hospital Quetta. Methodology: The current study was cross sectional study carried out at the pediatrics department, Sandeman Provencial Hospital Quetta from 16th May 2017 to 16th Nov 2017. All in patients who fulfilled the inclusion criteria in the Department of pediatrics, Sandeman Provinvical Hospital Quetta were included in the study. After taking informed written consent, bubble continuous positive airway pressure was used in all the included patients to assess the outcome variable i.e survival. All the collected information was entered in the prescribed Performa. Results: In the current study, totally, 138 patients with respiratory distress were included. 84 patients (60.9%) were males & 54 (39.1%) were females, with the mean age of 6.98+2.78 years. The mean gestational age of mother was 38.5±1.26 weeks, the mean duration of achieving 21% O2 was 81.60 (±0.81) hours, mean stay in hospital was 22.07 (±1.7) days. In our study 95 neonates (68.8%) survived.