Introduction Vaccine hesitancy is defined as “delay in acceptance or refusal of vaccination despite the availability of vaccination services”. The low acceptance rate of covid-19 vaccination, reported in many countries, is a big challenge in efforts toward putting end to the pandemic. Objective In this study, we aim to find the acceptance and hesitancy rates toward Covid-19 vaccine along with its reasons among medical students in Kabul. Methodology In this cross-sectional study that was conducted among medical students of five randomly selected universities in Kabul, a total of 459 medical students completed the questionnaire. Results The hesitancy rate for covid-19 vaccine among medical students was 42.3%, hesitancy rate in males was more than in female students. The essential reason for refusing of the vaccine was concerns about safety and adverse effect of the vaccine (62.3%). More than half of the participants (51.5%) have already been vaccinated. In 60.2% of participants, protection against the COVID-19 virus was the main reason for accepting the vaccine. This study indicates that social media was the leading source (64.3%) of information about vaccine hesitancy. Conclusion This study indicates a high level of hesitancy toward the COVID-19 vaccine among medical students. It is strongly advised to deliver accurate information on the safety and effectiveness of COVID-19 vaccines to the community especially, medical students.
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