Objective: The objective of this study was to find the profile of childhood cancers in the Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Srinagar, India, from 2010 to 2019. Materials and Methods: It was a retrospective study where medical records of children with cancer that was registered in regional cancer center SKIMS, Srinagar, from January 2010 to December 2019, aged 0–14 years diagnosed using histological or cytological examinations were reviewed to gather data on the prevalence and pattern of tumors according to age, sex, and rural and urban distribution. Results: There were 38,962 new confirmed cases registered in the regional cancer center at SKIMS, Srinagar, during these 10 years. Among which 1036 were below 15 years of age. An average of 103 cases attended per year. Overall pediatric tumors were 2.66% of total cancers. The frequency of cancer was found to be higher among boys (57.9%) than girls (42.1%) with a ratio of 1.37:1. The majority of the children were from rural areas (84.9%) compared to (15.1%) from urban areas. The results showed that leukemia (36.6%), lymphoma (19.8%), and bone tumors (9.3%) were the commonly found childhood cancers among the children attended at SKIMS, Srinagar, during these 10 years. Other less commonly found tumors were central nervous system tumors (6.7%), Wilms' tumor (4.1%), retinoblastoma (3.7%), and cancer of unknown primary with secondaries (1.5%). Conclusions: Leukemia, lymphoma, and bone tumors were the most common malignancies reported in the children treated at our cancer center.

Aim and Objectives: The aims and objectives of the study were to assess the progression-free survival (PFS) and overall survival, local tumor control rate (response rate), effect on the quality of life, and treatment-related toxicities in all patients diagnosed with recurrent high-grade gliomas (HGGs). Methodology: The present study was conducted between September 2017 and July 2019 in the Department of Radiation Oncology, Sheri Kashmir Institute of Medical Sciences and included a total of 22 patients. The study included recurrent HGGs (Grade III/IV) Operated Cases of Grade III and Grade IV. Results: The majority of our patients were between the age group of 40–60 years (45.5%). There were 12 males (54.5%) and 10 females (45.5%). GBM was the most common diagnosis in 13 (59.1) patients and 9 (40.9%) were anaplastic astrocytoma. Sixteen patients were diagnosed as recurrent HGG radiologically. Sixteen (72.7%) patients achieved partial response and 6 (27.3%) achieved stable disease. The median PFS was 2.8 months and the median overall survival was 4.2 months. Conclusion: Reirradiation is one of the treatment options for recurrent HGGs and conformal intensity-modulated radiotherapy can be effective treatment modality for recurrent high-grade brain tumors with only mild side effects. Although survival is better in patients with good performance status and young age.

Background: Germ cell tumors (GCTs) are a heterogeneous group of neoplasms, which occur in the gonads, and at extra gonadal sites of the body. The aim of the study was to observe the different histopathological patterns of various GCTs in the body at all possible sites and to know their IHC staining patterns.Methods: The study was conducted for a period of 5 years from 2015 to 2019 and was an observational study. The recorded data was compiled and entered in a spreadsheet and then exported to data editor of SPSS Version 20.0. Continuous variables were expressed as mean SD and categorical variables were summarized as frequencies and percentages. Graphically the data was presented by bar and pie diagrams Chi-square test or Fisher’s exact test was applied for comparing categorical values. P<0.05 was considered statistically significant. All p values were 2 tailed.Results: A total of 93 cases were analyzed and the mean age of the patients was 27.8 years. Mature cystic teratoma was the most common histopathological variant and was mostly seen in the ovaries. There was a difference in age predilection of benign and malignant tumors. Most of the malignant GCTs were gonadal while EGCTs were likely to be benign. MGCTs (mixed GCTs) were mostly testicular in origin with only one MGCT being extragonadal.Conclusions: Mature cystic teratomas were the most frequent GCTs with frequent site being in ovaries. Out 0f 18 EGCTs only 2 were malignant, rest all were mature cystic teratomas.