Background: Several studies showed that 4% articaine had greater tissue penetration than other anesthetics. Objectives: The current study aimed to compare the efficacy of buccal injection of local 4% articaine and 2% lidocaine on the numbness of palatal tissue. Materials and Methods: One hundred-ninety-six patients were randomly divided into two groups of 100. A group received 4% articaine and the other group received just 2% lidocaine buccal injection. The examination of palatal tissue numbness was conducted by decole and luxation of palatal tissue. Pain assessment was conducted by verbal response scale (VRS). Results:The Chi-square test showed a significant relationship between the type of anesthesia and pain (P < 0.0001). The patients treated with 4% articaine had less pain. Conclusions: Although 4% articaine can cause more anesthesia of palatal tissue compared to 2% lidocaine, its routine use is not recommended due to its incomplete success.