Article Info Background: Occupational burnout is an emotional response to chronic occupational stress. The aim of this study was determine the rate of occupational burnout among physicians working in Rafsanjan University hospitals Rafsanjan, Iran, and its correlation with personality dimensions: 2016. Materials and Methods: In this descriptive and correlational study, 161 physicians were recruited using the census method. After obtaining informed consent, respondents filled in the Revised NEO Personality Inventory (NEO PI-R) and Maslach Burnout Inventory. Data were analyzed using independent t-test, one-way analysis of variance (ANOVA), and multiple linear regression. Results: Gender, age, and working experience did not have a significant association with occupational burnout (P > 0.050). Moreover, 16 (9.9%), 139 (86.3%), and 6 (3.7%) of the physicians had low, moderate, and high occupational burnout, respectively. The mean score of emotional fatigue of women (P = 0.015) and individuals aged 35-50 years (P = 0.400) was higher. The association of job burnout was significant and inverse with all dimensions of personality and significant with the personality dimension of neuroticism (P < 0.001). Regression analysis indicated that 23.8% of occupational burnout was predictable by the personality dimension of extroversion [P = 0.021]. Conclusions: Ninety percent of the physicians had moderate to severe occupational burnout that was related to some personality dimensions. Since doctors play an important role in promoting community health, it seems necessary that trustee organizations, while investigating the factors affecting occupational burnout and trying to improve the status quo, use personality assessment as part of the appointment and organization process.

Context: The aim of this review was to address the recent data regarding the role of IL-17A in the pathogenesis of depression and its complications, such as cancer. Evidence Acquisition: This review article summarizes the recent data on the role of IL-17A in depression, using the PubMed and Google Scholar databases. Results: It has been documented that depression may alter the immune response via unknown mechanism/s. It is possible that immune responses and depression are linked via several molecules, including cytokines. IL-17A, a pro-inflammatory cytokine, participates in the pathogenesis of several inflammatory-based diseases, such as autoimmunity. Conclusions: Due to the comorbidity of depression and chronic inflammatory processes, and depression's effect on the immune system, it may be hypothesized that the IL-17A cytokine plays a key role in the pathogenesis of depression.