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Background To evaluate the effect of daclatasvir and sofosbuvir on auditory function in hepatitis C patients. Thirty hepatitis C virus (HCV) patients were included in this study with age ranged from 22 to 55 years. All patients underwent full audiological evaluation before beginning and after completion of their treatment with combination of daclatasvir and sofosbuvir. Result When the results of audiological data were compared before and after treatment, we found that; there were statistically significant differences in the pure tone audiometry (PTA) threshold and ART bilaterally mainly in the high frequency region. Transient evoked otoacoustic emission (TEOAE) reproducibility showed a statistically significant difference bilateral. However, there was no statistically significant difference in the Auditory Brainstem Response (ABR) findings. Conclusion and recommendations The combination therapy of daclatasvir and sofosbuvir used in patients with HCV led to deterioration in the hearing threshold in the basic audiological tests (PTA and immitancemetry). In addition, it had an adverse effect on the cochlear OHCs, with no affection on auditory nerve, brain stem functions or in sub-thalamic function, it seems that it had no effect, we cannot confirm. The study evaluate hearing at the end of treatment immediately. We recommend performing a routine monitoring of auditory functions in HCV patients treated with daclatasvir and sofosbuvir combination by specialist for early detection of auditory changes to avoid further damage to auditory system.

Introduction: One of the main characteristic of auditory neuropathy spectrum disorder (ANSD) is a significantly impaired temporal processing ability with subsequent difficulty in speech understanding particularly in noise. Enhancing temporal properties in clear speech can be beneficial in enhancing speech intelligibility in ANSD patients. Clear speech was developed in English language. Objective: To develop and standardize Arabic clear speech materials and to evaluate performance of patients with ANSD and sensory neural hearing loss (SNHL) in developed Arabic clear speech. Patients and Methods:The present study was conducted in three phases. Phase one; developing and recording of clear and conversational Arabic speech materials. Phase two; establishing norms in the developed materials by evaluation of 30 adult normal subjects. Phase three; comprised evaluation of performance of 30 adult SNHL patients and 40 adult patients with ANSD. Patients were tested in quiet as well as in noisy listening conditions. Results: Clear speech advantage in ANSD patients was 16.7% over conversational speech, while it was 5% in patients with SNHL. All patients with ANSD performed more poorly in noise at all signal to noise ratios (SNRs). Conclusion:The advantage of clear speech over conversational speech was more evident in ANSD patients than SNHL group. ANSD patients derive this advantage from enhancement of temporal properties in clear speech most likely. This study suggested using clear speech in remediation of patients with ANSD in order to improve their ability to communicate.